Mast Therapeutics To Present MST-188 Data At 2014 American Society Of Hematology Conference

MST-188 Significantly Decreased Thrombin Generation in Blood of Sickle Cell Anemia Patients

SAN DIEGO, Nov. 17, 2014 /PRNewswire/ -- Mast Therapeutics, Inc. (NYSE MKT: MSTX), a clinical-stage biopharmaceutical company, today announced that it will be presenting data from an ex vivo study of MST-188 (vepoloxamer), its lead product candidate, at the 56th Annual Meeting of the American Society of Hematology (ASH) taking place December 6 – 9, 2014 in San Francisco, California. The abstract entitled "Pro-coagulant Actions of Circulating Microparticles in Sickle Cell Anemia and Sepsis Associated Coagulopathy and their Modulation by a Triblock Polymer MST-188," will be presented as part of the Oral and Poster Abstracts Program on Sunday December 7, 2014 in Session 321: Blood Coagulation and Fibrinolytic Factors: Poster II, from 6:00-8:00pm PST in the Moscone Center, West Building, Level 1. In addition, the abstract has also been published in the November 14, 2014 supplemental volume of the journal Blood.

In the ex vivo study, which was conducted at Loyola University Medical Center, the supplementation of MST-188 to blood samples collected from healthy normal individuals, sickle cell anemia (SCA) patients and sepsis associated coagulopathy (SAC) patients resulted in significant decrease in thrombin generation and marked decrease of functioning microparticles. The decrease in thrombin generation with MST-188 supplementation ranged from 24-55%. Thrombin is an enzyme that controls the conversion of fibrinogen to fibrin, which promotes blood clotting. Circulating microparticles (MPs) represent vesicles and cellular fragments generated in microvascular angiopathic conditions which facilitate pro-coagulant actions and contribute to thrombin generation and associated inflammatory processes. MST-188 is a triblock polymer with affinity to hydrophobic surfaces which are generated in microangiopathic conditions and may also interact with the phospholipid component of MPs. To test the hypothesis that MST-188 may decrease the pro-coagulant effects of MPs, a functional method to access MPs levels and a thrombin generation assay was used.

Martin Emanuele, Ph.D., Senior Vice President, Development, said: "These results suggest that MST-188 (vepoloxamer) antagonizes the procoagulant properties of microparticles formed in sepsis and during sickle cell crisis. This is important because dysfunctional coagulation is a key part of the pathology underlying 'sludged' blood flow (especially in the microcirculation) in both conditions."

Abstract Information:

  • The abstract entitled "Pro-coagulant Actions of Circulating Microparticles in Sickle Cell Anemia and Sepsis Associated Coagulopathy and their Modulation by a Triblock Polymer MST-188" will be presented by Jaweed Fareed, Ph.D., Professor of Pathology and Pharmacology at Loyola University Stritch School of Medicine;
  • The abstract is available on the Company's website at

About Mast Therapeutics
Mast Therapeutics, Inc. is a publicly traded biopharmaceutical company headquartered in San Diego, California.  The Company is leveraging the MAST (Molecular Adhesion and Sealant Technology) platform, derived from over two decades of clinical, nonclinical and manufacturing experience with purified and non-purified poloxamers, to develop MST-188, its lead product candidate, for serious or life-threatening diseases and conditions typically characterized by impaired microvascular blood flow and damaged cell membranes. 

The Company is enrolling subjects in EPIC, a pivotal Phase 3 study of MST-188 in sickle cell disease, and in a Phase 2 study to evaluate whether MST-188 improves the effectiveness of recombinant tissue plasminogen activator therapy in patients with acute limb ischemia.  The Company also is planning to initiate a Phase 2 clinical study of MST-188 in patients with acute decompensated heart failure in the first half of 2015. More information can be found on the Company's web site at (Twitter: @MastThera

Mast Therapeutics™ and the corporate logo are trademarks of Mast Therapeutics, Inc.

Forward Looking Statements
Mast Therapeutics cautions you that statements included in this press release that are not a description of historical facts are forward-looking statements that are based on the Company's current expectations and assumptions. Such forward-looking statements include, but are not limited to, statements relating to prospects for successful development of the Company's product candidates, including MST-188 in sickle cell disease, and anticipated timing of achievement of development milestones, including commencement of clinical studies. Among the factors that could cause or contribute to material differences between the Company's actual results and the expectations indicated by the forward-looking statements are risks and uncertainties that include, but are not limited to: the uncertainty of outcomes in ongoing and future studies of the Company's product candidates and the risk that its product candidates, including MST-188, may not demonstrate adequate safety, efficacy or tolerability in one or more such studies, including EPIC; delays in the commencement or completion of clinical studies, including as a result of difficulties in obtaining regulatory agency agreement on clinical development plans or clinical study design, opening trial sites, enrolling study subjects, manufacturing sufficient quantities of clinical trial material, being subject to a "clinical hold," and/or suspension or termination of a clinical study, including due to patient safety concerns or lack of funding; the potential for institutional review boards or the FDA or other regulatory agencies to require additional nonclinical or clinical studies prior to initiation of a planned clinical study of a product candidate; the risk that, even if clinical studies are successful, the FDA or other regulatory agencies may determine they are not sufficient to support a new drug application; the potential that, even if clinical studies of a product candidate in one indication are successful, clinical studies in another indication may not be successful; the Company's reliance on contract research organizations (CROs), contract manufacturing organizations (CMOs), and other third parties to assist in the conduct of important aspects of development of its product candidates, including clinical studies, manufacturing, and regulatory activities for its product candidates, and that such third parties may fail to perform as expected; the Company's ability to obtain additional funding on a timely basis or on acceptable terms, or at all; the potential for the Company to delay, reduce or discontinue current and/or planned development activities, including clinical studies, partner its product candidates at inopportune times or pursue less expensive but higher-risk and/or lower return development paths if it is unable to raise sufficient additional capital as needed; the risk that, even if the Company successfully develops a product candidate in one or more indications, it may not realize commercial success with its products and may never generate revenue sufficient to achieve profitability; the risk that the Company is not able to adequately protect its intellectual property rights relating to the MAST platform and MST-188 or AIR001 and prevent competitors from duplicating or developing equivalent versions of its product candidates; and other risks and uncertainties more fully described in the Company's press releases and periodic filings with the Securities and Exchange Commission. The Company's public filings with the Securities and Exchange Commission are available at

You are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date when made. Mast Therapeutics does not intend to revise or update any forward-looking statement set forth in this press release to reflect events or circumstances arising after the date hereof, except as may be required by law.

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SOURCE Mast Therapeutics, Inc.

Ioana C. Hone, Mast Therapeutics, +1-858-552-0866 Ext. 303,