Filing

VIA FACSIMILE AND EDGAR

October 12, 2011

Johnny Gharib

Division of Corporation Finance

United States Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Facsimile: (202) 772-9198

Registration Statement on Form S-3, as amended by Amendment No. 1 filed on

October 6, 2011 (File No. 333-174203)

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, ADVENTRX Pharmaceuticals, Inc. (the “Company”) hereby requests acceleration of the above-referenced registration statement on Form S-3, so that it will become effective at 8:00 a.m., Eastern time, on Thursday, October 13, 2011, or as soon thereafter as practicable.

The Company hereby acknowledges that: (i) should the Commission or the staff, acting pursuant to delegated authority, declare the filing effective, it does not foreclose the Commission from taking any action with respect to the filing; (ii) the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and (iii) the Company may not assert the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

Thank you for your assistance. If you should have any questions, please call Shana Hood, the Company’s Associate General Counsel, at (858) 768-6338.

Jeff Thacker, DLA Piper LLP (US)