Therapeutic focus

Savara Pharmaceuticals / Indications / Therapeutic focus

Therapeutic focus

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We develop innovative drugs for the treatment of rare respiratory diseases.

Savara focuses on developing new inhalation treatments for patients who suffer from rare and serious respiratory diseases. We are advancing a pipeline based on three compounds that have been widely used before as active pharmaceutical ingredients in medicinal products licensed for systemic use but, never in medicinal products licensed for inhalation. By delivering these compounds directly to the lungs of the patients, the clinical efficacy is expected to improve and the adverse effects are expected to be reduced compared to systemic use.

The compounds are:

  1. Vancomycin
  2. GM-CSF
  3. Factor VIIa

We reposition these compounds considering:

  1. New unique formulations
  2. New administration routes
  3. New indications

We develop the compounds for the treatment of patients suffering from:

  1. Cystic fibrosis (CF)
  2. Pulmonary alveolar proteinosis (PAP)
  3. Diffuse alveolar hemorrhage (DAH)

All of these conditions are serious and have a high medical priority due to the lack of effective treatments or due to the invasiveness or risks associated with currently available therapies. The conditions are rare, and orphan drug designations have been or will be obtained by the EMA and FDA for all three indications.

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